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Antibodies and myelination: facts and misacts.

Abstract
Polyreactive (auto)antibodies are frequently found in healthy subjects and are bona fide considered to be nonpathogenic. However, autoreactive B cells and circulating (auto)antibodies have been associated with several neurological syndromes, including demyelinating disorders. Whether these antibodies can have a real impact on disease development is still a matter of debate. Here, we briefly summarize some of the most recently published data on both the deleterious and the protective effects of antibodies in autoimmune demyelinating disorders of the central nervous system.
AuthorsS Pluchino, L Zanotti, G Martino
JournalNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 24 Suppl 4 Pg. S231-3 (Oct 2003) ISSN: 1590-1874 [Print] Italy
PMID14598049 (Publication Type: Journal Article, Review)
Chemical References
  • Autoantibodies
  • Immunoglobulins, Intravenous
Topics
  • Animals
  • Autoantibodies (adverse effects, pharmacology)
  • B-Lymphocytes (immunology)
  • Controlled Clinical Trials as Topic
  • Demyelinating Autoimmune Diseases, CNS (physiopathology)
  • Demyelinating Diseases (immunology, physiopathology)
  • Drug Administration Schedule
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Nervous System Diseases (physiopathology)

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