The relevance of cell size on ultrasound-induced hemolysis in mouse and human blood in vitro.

Abstract

This paper describes a further test of the hypothesis that cell size is an important physical parameter in ultrasound (US)-induced hemolysis, that is, the larger the cell the greater the potential for sonolysis by a cavitational mechanism. Mouse (M) and human (Hu) erythrocytes in vitro were used; their mean corpuscular volumes were 49.0 and 89.5 fL, respectively. At a US exposure in vitro in the presence of Albunex that yielded an average of 36.8% hemolysis for M blood, the Hu blood yielded an average of 54.0% hemolysis. The data supported the hypothesis. This paper also briefly discusses the difficulty of extrapolating sonolytic in vitro results to those derived in vivo.

• Authors: Morton W Miller, Linda F Battaglia
• Journal: Ultrasound in medicine & biology (Ultrasound Med Biol) Vol. 29 Issue 10 Pg. 1479-85 (Oct 2003) ISSN: 0301-5629 [Print] England
• PMID: 14597345 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Contrast Media

Topics

• Animals
• Cell Size
• Contrast Media
• Erythrocyte Indices
• Erythrocytes (cytology, physiology)
• Hemolysis
• Humans
• In Vitro Techniques
• Mice
• Mice, Inbred C57BL
• Species Specificity
• Ultrasonography