Circulating concentrations of cardiac proteins indicate the severity of congestive heart failure.

Abstract

OBJECTIVE:

To test the hypothesis that myocardium specific proteins may be useful markers for evaluating the severity of congestive heart failure.

METHODS:

Serum concentrations of myosin light chain I (MLC-I), heart fatty acid binding protein (H-FABP), creatine kinase isoenzyme MB (CK-MB), and troponin T (TnT) and plasma concentrations of brain natriuretic peptide (BNP) were determined in 48 patients with acute deterioration of congestive heart failure, both before and after effective treatment.

RESULTS:

Before treatment, MLC-I (mean (SEM) 3.2 (2.2) microg/l), H-FABP (9.0 (3.5) microg/l), TnT (30 (21) ng/l), and BNP (761 (303) ng/l) were higher than the normal reference range, and concentrations of CK-MB (5.4 (2.9) microg/l) were near normal. Treatment of congestive heart failure with conventional medication significantly decreased the concentrations of MLC-I (1.2 (0.3) microg/l, p < 0.0001), H-FABP (6.0 (2.0) microg/l, p < 0.0001), CK-MB (2.9 (1.5) microg/l, p < 0.0001), TnT (9 (1) ng/l, p < 0.001), and BNP (156 (118) ng/l, p < 0.0001). The decreases in H-FABP and CK-MB concentrations after treatment correlated with the decrease in BNP concentrations (p < 0.05). The absolute concentrations of MLC-I, H-FABP, CK-MB, and TnT correlated positively with those of BNP (p < 0.01).

CONCLUSIONS:

These findings suggest that MLC-I, H-FABP, CK-MB, and TnT may be used as reliable markers for the evaluation of the severity of congestive heart failure.

• Authors: T Goto, H Takase, T Toriyama, T Sugiura, K Sato, R Ueda, Y Dohi
• Journal: Heart (British Cardiac Society) (Heart) Vol. 89 Issue 11 Pg. 1303-7 (Nov 2003) ISSN: 1468-201X [Electronic] England
• PMID: 14594884 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Carrier Proteins
• FABP7 protein, human
• Fatty Acid-Binding Protein 7
• Fatty Acid-Binding Proteins
• Isoenzymes
• Myosin Light Chains
• Neoplasm Proteins
• Troponin T
• Tumor Suppressor Proteins
• hALC-1 protein, human
• Natriuretic Peptide, Brain
• Creatine Kinase
• Creatine Kinase, MB Form

Topics

• Aged
• Biomarkers (blood)
• Carrier Proteins (blood)
• Creatine Kinase (blood)
• Creatine Kinase, MB Form
• Fatty Acid-Binding Protein 7
• Fatty Acid-Binding Proteins
• Female
• Heart Failure (blood, drug therapy)
• Humans
• Isoenzymes (blood)
• Male
• Myosin Light Chains (blood)
• Natriuretic Peptide, Brain (blood)
• Neoplasm Proteins
• Prognosis
• Troponin T (blood)
• Tumor Suppressor Proteins