[Conditioning of chronic wounds with proteolytic enzymes].

Abstract

In the past few years, several different proteolytic enzymes have been shown to be effective in conditioning the chronic wound beds. The use of proteolytic enzymes in wound-bed preparation enables a selective painless debridement. Moreover multiple positive effects on formation of granulation tissue and re-epithelialization have been observed. Therefore, a faster overall healing of chronic wounds may result. Moreover, numerous positive effects on a rapid induction of granulation are discussed. The supporting data do not fulfill the criteria of evidence-based medicine. For most chronic wounds today, enzymatic debridement represents a first choice method especially for outpatients and perhaps in combination with surgical debridement.

• Authors: J Dissemond, M Goos
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 54 Issue 11 Pg. 1073-9 (Nov 2003) ISSN: 0017-8470 [Print] Germany
• Vernacular Title: Konditionierung chronischer Wunden mittels proteolytischer Enzyme.
• PMID: 14593465 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Peptide Hydrolases

Topics

• Administration, Topical
• Chronic Disease
• Debridement
• Humans
• Peptide Hydrolases (administration & dosage)
• Wound Healing (drug effects)
• Wounds and Injuries (drug therapy)