Abstract | BACKGROUND: MATERIALS AND METHODS: Thirty-seven patients were studied measuring serum and wound drainage fluid VEGF by enzyme-linked immunosorbent assay preoperatively and on the 1st, 3rd, 5th and 7th postoperative days. RESULTS: Serum and wound fluid VEGF levels increased significantly by the 3rd postoperative day and continued to rise during the conduct of the study with wound fluid concentrations always exceeding serum levels. The kinetics of VEGF increases were similar in both types of hernia repair; however, serum and wound levels rose slightly earlier in the mesh repair group. CONCLUSIONS: Steadily increasing levels of VEGF are detected during the early proliferative phase of wound healing in both serum and wound fluid. It is unknown whether either is predictive for delayed hernia recurrence.
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Authors | A J Karayiannakis, A Zbar, A Polychronidis, C Simopoulos |
Journal | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
(Eur Surg Res)
2003 Nov-Dec
Vol. 35
Issue 6
Pg. 492-6
ISSN: 0014-312X [Print] Switzerland |
PMID | 14593233
(Publication Type: Journal Article)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Chemical References |
- Vascular Endothelial Growth Factor A
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Ascitic Fluid
(metabolism)
- Drainage
- Female
- Hernia, Ventral
(metabolism, surgery)
- Humans
- Kinetics
- Male
- Middle Aged
- Prospective Studies
- Surgical Mesh
- Vascular Endothelial Growth Factor A
(blood, metabolism)
- Wound Healing
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