HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Coexistence of familial hypertrophic cardiomyopathy and vasospastic angina pectoris in two brothers.

Abstract
Two brothers had familial hypertrophic cardiomyopathy and vasospastic angina pectoris concurrently. Their family history showed that one of their sisters had hypertrophic cardiomyopathy and another brother died suddenly at age 52. The clinical diagnosis of hypertrophic cardiomyopathy was confirmed by an echocardiogram and left ventriculography. They had typical chest pain at rest, and a significant vasospasm of coronary arteries with chest pain and obvious ST-T changes in the electrocardiograms was provoked by intracoronary injection of acetylcholine in both patients. The administration of a calcium antagonist and nitrate was effective for ameliorating chest pain with no cardiovascular events during the follow up period of more than 3 years. Although underlying pathophysiologic abnormalities of familial hypertrophic cardiomyopathy and vasospastic angina pectoris are considered to be transmitted genetically, the genetic backgrounds of these cases remain to be clarified.
AuthorsNobuaki Suzuki, Shinji Seto, Yuji Koide, Osami Sato, Hisataka Hirano, Hiroaki Kawano, Katsusuke Yano
JournalJapanese heart journal (Jpn Heart J) Vol. 44 Issue 5 Pg. 775-82 (Sep 2003) ISSN: 0021-4868 [Print] Japan
PMID14587659 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Calcium Channel Blockers
  • Nitrates
Topics
  • Aged
  • Angina Pectoris (complications, drug therapy, genetics)
  • Calcium Channel Blockers (therapeutic use)
  • Cardiomyopathy, Hypertrophic, Familial (complications, drug therapy)
  • Coronary Angiography
  • Coronary Vasospasm (complications, drug therapy, genetics)
  • Electrocardiography
  • Humans
  • Male
  • Nitrates (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: