Abstract | OBJECTIVE: STUDY DESIGN: A 1:1 matched case-control study was performed comparing multiple marker screening test results in 34 HIV-positive women with age- and race-matched HIV-negative controls. Individual serum markers and screen positive rates for both the triple and quad screens were compared among the cases and controls. RESULTS: In each group, there were 19 women with triple screens and 15 with quad screens. Serum hCG multiples of the median were significantly higher in the HIV-positive compared with the HIV-negative women (P=.033). There was no difference in screen positive rates between the cases and controls using the triple screen, but there was a significantly higher overall screen positive rate in the HIV-positive group when the quad screen was used (33% vs 7%, P=.046). CONCLUSION: There is a significantly higher rate of overall quad screen positivity on multiple-marker screening among HIV-positive women compared with a matched control group.
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Authors | Mark H Yudin, Tracy L Prosen, Daniel V Landers |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 189
Issue 4
Pg. 973-6
(Oct 2003)
ISSN: 0002-9378 [Print] United States |
PMID | 14586337
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Chorionic Gonadotropin
- alpha-Fetoproteins
- Inhibins
- Estriol
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Topics |
- Acquired Immunodeficiency Syndrome
(blood)
- Biomarkers
(analysis)
- Case-Control Studies
- Chorionic Gonadotropin
(blood)
- Estriol
(blood)
- Female
- HIV Infections
(blood)
- HIV Seronegativity
- HIV Seropositivity
(blood)
- Humans
- Inhibins
(blood)
- Pregnancy
- Pregnancy Complications, Infectious
(blood)
- alpha-Fetoproteins
(analysis)
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