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Multiple-marker screening in human immunodeficiency virus-positive pregnant women: Screen positivity rates with the triple and quad screens.

AbstractOBJECTIVE:
The study was undertaken to determine the screen-positive rates of multiple-marker screening tests in pregnant women who are positive for human immunodeficiency virus (HIV) at our institution for open neural tube defects and aneuploidy, for both triple (alpha-fetoprotein, human chorionic gonadotropin [hCG], unconjugated estriol) and quad (alpha-fetoprotein, hCG, unconjugated estriol, inhibin A) screens, and to compare these rates with a matched control group.
STUDY DESIGN:
A 1:1 matched case-control study was performed comparing multiple marker screening test results in 34 HIV-positive women with age- and race-matched HIV-negative controls. Individual serum markers and screen positive rates for both the triple and quad screens were compared among the cases and controls.
RESULTS:
In each group, there were 19 women with triple screens and 15 with quad screens. Serum hCG multiples of the median were significantly higher in the HIV-positive compared with the HIV-negative women (P=.033). There was no difference in screen positive rates between the cases and controls using the triple screen, but there was a significantly higher overall screen positive rate in the HIV-positive group when the quad screen was used (33% vs 7%, P=.046).
CONCLUSION:
There is a significantly higher rate of overall quad screen positivity on multiple-marker screening among HIV-positive women compared with a matched control group.
AuthorsMark H Yudin, Tracy L Prosen, Daniel V Landers
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 189 Issue 4 Pg. 973-6 (Oct 2003) ISSN: 0002-9378 [Print] United States
PMID14586337 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • Chorionic Gonadotropin
  • alpha-Fetoproteins
  • Inhibins
  • Estriol
Topics
  • Acquired Immunodeficiency Syndrome (blood)
  • Biomarkers (analysis)
  • Case-Control Studies
  • Chorionic Gonadotropin (blood)
  • Estriol (blood)
  • Female
  • HIV Infections (blood)
  • HIV Seronegativity
  • HIV Seropositivity (blood)
  • Humans
  • Inhibins (blood)
  • Pregnancy
  • Pregnancy Complications, Infectious (blood)
  • alpha-Fetoproteins (analysis)

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