Synthesis and biological evaluation of 2'-methyl taxoids derived from baccatin III and 14beta-OH-baccatin III 1,14-carbonate.

Abstract	A series of 2'-methyl taxoids were synthesized and essayed for growth inhibition experiments conducted in human ovarian cancer cell line A2780wt and its counterparts A2780cis, A2780tax, and A2780adr, resistant to cisplatin, paclitaxel, and doxorubicin, respectively, to test the effect of this substituent on the antitumor activity. Additional experiments were performed on MCF-7 human breast cancer cell line and MCF7-R resistant to doxorubicin. In several cases these taxoids were more active than paclitaxel showing subnanomolar IC(50) values.
Authors	Arturo Battaglia, Ralph J Bernacki, Carlo Bertucci, Ezio Bombardelli, Samanta Cimitan, Cristiano Ferlini, Gabriele Fontana, Andrea Guerrini, Antonella Riva
Journal	Journal of medicinal chemistry (J Med Chem) Vol. 46 Issue 23 Pg. 4822-5 (Nov 06 2003) ISSN: 0022-2623 [Print] United States
PMID	14584931 (Publication Type: Journal Article)
Chemical References	Alkaloids Antineoplastic Agents Taxoids baccatin III
Topics	Alkaloids (chemical synthesis, chemistry, pharmacology) Antineoplastic Agents (chemical synthesis, chemistry, pharmacology) Cell Line, Tumor Drug Resistance, Neoplasm Humans Structure-Activity Relationship Taxoids (chemical synthesis, chemistry, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!