[An experimental study of the hepatoprotective properties of phytoecdysteroids and nerobol in carbon tetrachloride-induced liver lesion].

Abstract

The phytoecdisteroids ecdisterone, turkesterone and cyasterone were administered in a dose of 5 mg/kg per os to rats with hepatitis induced by subcutaneous injections of CCl4. Similarly to the anabolic drug nerobol (10 mg/kg), the above agents not only interfere with the manifestation of the hepatic action of CCl4 (in this case the effect of the phytoecdisteroids is more remarkable) but also favour a more rapid normalization, as compared to the control, of functional and metabolic disorders in the liver. The phytoecdisteroids and nerobol noticeably stimulate the recovery of bile secretion, the synthesis of bilirubin and bile acids, cholesterol excretion.

• Authors: V N Syrov, Z A Khushbaktova, A N Nabiev
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1992 May-Jun Vol. 55 Issue 3 Pg. 61-5 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Eksperimental'noe izuchenie gepatoprotektornykh svoĭstv fitoékdisteroidov i nerobola pri porazhenii pecheni chetyrekhkhloristym uglerodom.
• PMID: 1458171 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antidotes
• Plant Extracts
• cyasterone
• Ecdysterone
• turkesterone
• Stigmasterol
• Methandrostenolone

Topics

• Animals
• Antidotes (therapeutic use)
• Carbon Tetrachloride Poisoning (complications, drug therapy, metabolism)
• Chemical and Drug Induced Liver Injury (drug therapy, etiology, metabolism)
• Drug Evaluation, Preclinical
• Ecdysterone (analogs & derivatives, therapeutic use)
• Liver (drug effects, metabolism)
• Male
• Methandrostenolone (therapeutic use)
• Plant Extracts (therapeutic use)
• Rats
• Stigmasterol (analogs & derivatives, therapeutic use)