Abstract |
Previous clinical evidence suggested that modafinil may improve clinical features of children with attention-deficit hyperactivity disorder. To test this hypothesis, a randomized, double-blind, placebo-controlled study design was used. Of 24 children initially randomized into the study, 11 control subjects and 11 treatment patients completed the study, with evaluation before medication and after 5 to 6 weeks. The average Test of Variables of Attention attention-deficit hyperactivity disorder z score improved by 2.53 S.D.s for the modafinil group compared with a decline of 1.02 for control patients (P < or = 0.02). Conners Rating Scales ADHD total t scores for the modafinil group improved from 76.6 to 68.2 compared with improvement from 77.7 to 76.0 for control subjects (P = 0.04). Ten of 11 treatment patients were reported as "significantly" improved, whereas eight of 11 control subjects were reported as manifesting "no" or "slight" improvement (P < 0.001). Adverse effects were few and manageable, with no anorexia. Modafinil may be a useful treatment for children with ADHD, particularly when anorexia limits use of stimulants.
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Authors | Thomas A Rugino, Teresa C Samsock |
Journal | Pediatric neurology
(Pediatr Neurol)
Vol. 29
Issue 2
Pg. 136-42
(Aug 2003)
ISSN: 0887-8994 [Print] United States |
PMID | 14580657
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Benzhydryl Compounds
- Central Nervous System Stimulants
- Modafinil
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Topics |
- Adolescent
- Attention Deficit Disorder with Hyperactivity
(drug therapy, psychology)
- Benzhydryl Compounds
(adverse effects, therapeutic use)
- Central Nervous System Stimulants
(adverse effects, therapeutic use)
- Child
- Double-Blind Method
- Female
- Humans
- Male
- Modafinil
- Neuropsychological Tests
- Surveys and Questionnaires
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