[Effects of trimebutine on colonic propulsion in mice].

Abstract

Effects of oral administration of trimebutine on colonic propulsion in conscious mice were studied by measuring the time required to evacuate a bead which had been inserted into the colon, and compared with those of metoclopramide and domperidone. In normal animals, trimebutine (10 and 50 mg/kg), metoclopramide (50 mg/kg) and domperidone (50 mg/kg) had no effect on the bead evacuation. Metoclopramide and domperidone at 30 mg/kg showed no effect on the delay of colonic propulsion induced by clonidine, while trimebutine (10 and 30 mg/kg) restored the delay significantly. Trimebutine also showed restoration of the delay induced by loperamide. On the acceleration of the propulsion induced by neostigmine, trimebutine (10 and 30 mg/kg) showed an inhibition. In addition, trimebutine (3-30 mg/kg) dose-dependently suppressed the development of soft feces and/or diarrhea induced by neostigmine. According to the results, it is concluded that trimebutine produces both acceleration and inhibition on the colonic propulsion in mice.

• Authors: K Yamada, Y Onoda
• Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi (J Smooth Muscle Res) Vol. 28 Issue 3 Pg. 87-93 (Jun 1992) ISSN: 0916-8737 [Print] Japan
• PMID: 1457960 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antidiarrheals
• Neostigmine
• Domperidone
• Metoclopramide
• Trimebutine

Topics

• Administration, Oral
• Animals
• Antidiarrheals
• Colon (drug effects, physiology)
• Domperidone (pharmacology)
• Dose-Response Relationship, Drug
• Gastrointestinal Motility (drug effects)
• Male
• Metoclopramide (pharmacology)
• Mice
• Neostigmine (antagonists & inhibitors)
• Trimebutine (administration & dosage, pharmacology)