Expression of NKB1 on peripheral T cells in patients with rheumatoid arthritis.

Abstract

NKB1 inhibits cytoxic activity of T lymphocytes mediated by superantigens, which is one of the contributing factors in the pathogenesis of rheumatoid arthritis (RA). In this study, we determined the expression of NKB1 on peripheral blood T cells in patients with RA. Our findings revealed that among patients with RA, NKB1(+) CD8(+ )T cells decreased significantly in comparison to controls (ratio: P < 0.05; absolute number: P < 0.005), and this decrease was not related to or influenced by HLA-Bw4 as a ligand of NKB1. This result may suggest that decreased expression of NKB1(+) CD8(+ )T cells contributes to the pathogenesis of RA mediated by the activation of CD8(+) T cells.

• Authors: Y Nakiri, H Kaneko, S Morimoto, J Suzuki, Y Tokano, H Hashimoto
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 22 Issue 4-5 Pg. 305-8 (Oct 2003) ISSN: 0770-3198 [Print] Germany
• PMID: 14579161 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers
• CD4 Antigens
• HLA-B Antigens
• Receptors, Immunologic
• Receptors, KIR
• Receptors, KIR3DL1

Topics

• Adult
• Aged
• Aged, 80 and over
• Arthritis, Rheumatoid (immunology, physiopathology)
• Biomarkers (analysis)
• CD4 Antigens (immunology)
• Case-Control Studies
• Cohort Studies
• Female
• HLA-B Antigens (immunology)
• Humans
• Lupus Erythematosus, Systemic (immunology, physiopathology)
• Male
• Middle Aged
• Probability
• Prognosis
• Receptors, Immunologic (immunology)
• Receptors, KIR
• Receptors, KIR3DL1
• Reference Values
• Sensitivity and Specificity
• Severity of Illness Index
• Statistics, Nonparametric