Weber-Christian disease presenting with ocular manifestations.

Abstract

A Japanese patient with Weber-Christian disease (WCD) presenting with ocular symptoms is reported. Panniculitis in the retrobulbar fat was diagnosed according to the histological findings from biopsy specimens, and improved over a month under steroid administration. Only three patients showing ocular manifestations have previously been reported. Panniculitis was in the late stage and a medium dose of prednisolone was effective in this patient. A biopsy of the orbital fat was useful for diagnosis. However, it is important to recognise that the stage of inflammation varies according to the fat tissue involved by WCD.

• Authors: T Yoshida, H Ito, Y Matsubara, Y Kitamura, A Sasaoka, T Chijiwa, K Hashimoto, T Komatsu, T Moriki, T Itahara
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 22 Issue 4-5 Pg. 339-42 (Oct 2003) ISSN: 0770-3198 [Print] Germany
• PMID: 14576996 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Prednisolone

Topics

• Aged
• Biopsy, Needle
• Diagnosis, Differential
• Exophthalmos (diagnosis)
• Female
• Follow-Up Studies
• Humans
• Immunohistochemistry
• Magnetic Resonance Imaging
• Panniculitis (diagnosis)
• Panniculitis, Nodular Nonsuppurative (diagnosis, drug therapy)
• Prednisolone (therapeutic use)
• Risk Assessment
• Severity of Illness Index
• Tomography, X-Ray Computed
• Treatment Outcome