Abstract | BACKGROUND: OBSERVATIONS: All biopsy specimens revealed an inflammatory response consistent with a localized hypersensitivity reaction; this was regardless of type of clinical lesion and included the patient with no clinical reaction. The pattern of inflammation resembled that of granuloma annulare and the recently described interstitial granulomatous drug reaction. Immunoperoxidase staining indicated that the inflammatory and collagen changes were greatest in areas where enfuvirtide was deposited. CONCLUSIONS: The pathologic changes and clinicopathologic correlations associated with injection site reactions in human enfuvirtide recipients have been described for the first time. This information also provides valuable insights into unusual pathogenic response to foreign antigens for patients with HIV.
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Authors | Russell A Ball, Tosca Kinchelow, ISR Substudy Group |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 49
Issue 5
Pg. 826-31
(Nov 2003)
ISSN: 0190-9622 [Print] United States |
PMID | 14576660
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HIV Envelope Protein gp41
- HIV Fusion Inhibitors
- Peptide Fragments
- Enfuvirtide
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Topics |
- Drug Eruptions
(etiology, immunology, pathology)
- Enfuvirtide
- HIV Envelope Protein gp41
(adverse effects)
- HIV Fusion Inhibitors
(adverse effects)
- Humans
- Injections, Subcutaneous
- Peptide Fragments
(adverse effects)
- Prospective Studies
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