Simulation of human gentamicin pharmacokinetics in an experimental Enterococcus faecalis endocarditis model.

Abstract

Significant differences between animal and human pharmacokinetics may be responsible for the conflicting results of experimental studies. This study determined the impact of human pharmacokinetic simulation (HPS) on gentamicin activity in an Enterococcus faecalis endocarditis model. The decrease in bacterial counts was greater with HPS than with a dose-equivalent regimen without HPS.

• Authors: Laurent Dubé, Jocelyne Caillon, Christèle Gras-Le Guen, Cédric Jacqueline, Marie-France Kergueris, Jean-Claude Granry, Gilles Potel, Denis Bugnon
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 47 Issue 11 Pg. 3663-6 (Nov 2003) ISSN: 0066-4804 [Print] United States
• PMID: 14576143 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Gentamicins

Topics

• Animals
• Anti-Bacterial Agents (pharmacokinetics, therapeutic use)
• Area Under Curve
• Colony Count, Microbial
• Disease Models, Animal
• Endocarditis, Bacterial (drug therapy, microbiology)
• Enterococcus faecalis
• Female
• Gentamicins (pharmacokinetics, therapeutic use)
• Gram-Positive Bacterial Infections (drug therapy, microbiology)
• Half-Life
• Rabbits