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Discrepant uptake between fluorine-18 fluorodeoxy glucose and Tc-99m sestamibi in bronchioloalveolar cell carcinoma.

Abstract
Several studies have shown the benefit of fluorine-18 fluorodeoxy glucose (FDG) imaging in the differentiation of solitary pulmonary nodules. The majority of malignant tumor have a higher glucose metabolic rate as compared to benign lesions. However, there is a considerable variety in glucose metabolic rate that depends on the aggressiveness and histological subtype of the tumor. Technetium-99m sestamibi (MIBI) is another tumor imaging agent for SPECT. We present a case of bronchioloalveolar cell carcinoma with a false negative finding in FDG imaging and a positive finding in MIBI imaging. This case clearly indicates that the FDG uptake and MIBI uptake might provide different information regarding characteristics of lung cancer.
AuthorsTakahiro Higuchi, Syoutoku Tagawa, Naohiro Yoshida, Tsutomu Araki, Taketsugu Tsuchiya, Koutarou Higashi, Junichi Taki, Seigo Kinuya, Kenichi Nakajima, Masatoshi Ikeda, Masanobu Namura, Norihisa Tonami
JournalAnnals of nuclear medicine (Ann Nucl Med) Vol. 17 Issue 6 Pg. 499-501 (Sep 2003) ISSN: 0914-7187 [Print] Japan
PMID14575387 (Publication Type: Case Reports, Comparative Study, Journal Article)
Chemical References
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Technetium Tc 99m Sestamibi
Topics
  • Adenocarcinoma, Bronchiolo-Alveolar (diagnostic imaging, pathology)
  • Aged
  • Diagnosis, Differential
  • False Negative Reactions
  • Fluorodeoxyglucose F18 (pharmacokinetics)
  • Humans
  • Lung Neoplasms (diagnostic imaging, pathology)
  • Male
  • Radiography
  • Radionuclide Imaging
  • Radiopharmaceuticals (pharmacokinetics)
  • Sensitivity and Specificity
  • Technetium Tc 99m Sestamibi (pharmacokinetics)

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