[Chronic manganese poisoning: autoradiographic quantification of cholinergic muscarinic receptors in mouse brain].

Abstract

Chronic administration of manganese chloride (5 mg Mn/kg body weight/day) during nine weeks, did not affect the [3H]-quinuclidinyl benzilate binding to muscarinic cholinergic receptors in mouse brain. The quantitation and anatomical distribution of the receptors were determined by autoradiographic methods on coronal sections of midbrain and olfactory bulb. It is concluded that, in our experimental conditions, no alteration in the density of the muscarinic cholinergic receptors is produced in the brain of manganese intoxicated mouse.

• Authors: G Cano, E Bonilla, F Castro, M Alburges, J K Wamsley
• Journal: Investigacion clinica (Invest Clin) Vol. 33 Issue 2 Pg. 69-79 ( 1992) ISSN: 0535-5133 [Print] Venezuela
• Vernacular Title: Intoxicación crónica con manganeso: cuantificación autorradiográfica de los receptores colinérgicos muscarínicos en el cerebro de ratón.
• PMID: 1457534 (Publication Type: Journal Article)

Chemical References

• Receptors, Cholinergic

Topics

• Animals
• Autoradiography
• Brain (diagnostic imaging)
• Male
• Manganese Poisoning
• Mice
• Radionuclide Imaging
• Receptors, Cholinergic (analysis, drug effects)
• Time Factors