[The use of depakene and depakene-chrono in idiopathic generalized epilepsy].

Abstract

During 5 years, 104 patients with different types of idiopathic generalized epilepsy were treated with depakine and depakine-chrono in monotherapy and polytherapy schedule. Thirty-three patients had childhood absence epilepsy, 34--juvenile absence epilepsy, 33--juvenile myoclonic epilepsy and 3--generalized convulsive seizures in wake up periods. Mean medication dose was 1200 mg daily. Significant improvement of the patient's state was revealed in 50% of the cases, being most efficient in patients with juvenile myoclonic epilepsy (60.6%) and in children absence epilepsy (57.5%). Indices of remission formation and quality changed in the same direction--complete remissions were more frequent in juvenile absence epilepsy. Depakine is concluded to be an effective medication for the treatment of idiopathic generalized epilepsy.

• Authors: N Iu Perunova
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 103 Issue 9 Pg. 45-7 ( 2003) ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Opyt primeneniia depakina i depakina-khrono pri idiopaticheskoĭ generalizovannoĭ épilepsii.
• PMID: 14571673 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• Valproic Acid

Topics

• Adolescent
• Adult
• Anticonvulsants (therapeutic use)
• Drug Administration Schedule
• Epilepsies, Myoclonic (drug therapy)
• Epilepsy, Generalized (drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Treatment Outcome
• Valproic Acid (administration & dosage, therapeutic use)