Abstract | GOALS: STUDY: Two groups of patients were evaluated. Group 1 consisted of 31 patients with newly diagnosed chronic pancreatitis who had never been treated with pancreatic enzyme preparations. Group 2 consisted of 39 patients whose disease was diagnosed on average 3.4 years before the start of the study. The latter group of patients had undergone pancreatic enzyme replacement therapy, but during follow-up this treatment proved to be insufficient. The dose of pancreatic enzyme replacement therapy was tailored in accordance with the degree of pancreatic exocrine insufficiency measured by means of exocrine pancreatic function tests. A modified European Organizaton for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) was used to assess QoL. RESULTS: The social functioning and financial strain were significantly better, while the levels of hope and confidence were significantly reduced in group 1 compared with group 2. A significant gain in body weight and a significantly reduced defecation rate were found in both groups one month after the beginning of the pancreatic enzyme replacement therapy when compared with the pretreatment values. The prevalence of general and disease-specific symptoms and the intensity of pain were reduced in both groups after one month of enzyme substitution therapy. The working ability, the financial strain and the overall QoL scores were improved significantly in both groups, while the cognitive functioning score was found to be significantly improved during the follow-up only in group 1. The overall increase in the QoL score correlated significantly with the increase in body weight and the decrease in defecation number in both groups. CONCLUSIONS:
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Authors | László Czakó, Tamás Takács, Peter Hegyi, László Prónai, Zsolt Tulassay, Lilla Lakner, Zoltán Döbrönte, Krisztina Boda, János Lonovics |
Journal | Canadian journal of gastroenterology = Journal canadien de gastroenterologie
(Can J Gastroenterol)
Vol. 17
Issue 10
Pg. 597-603
(Oct 2003)
ISSN: 0835-7900 [Print] Canada |
PMID | 14571298
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
- Lipase
- Amylases
- Endopeptidases
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Topics |
- Abdominal Pain
(prevention & control)
- Amylases
(therapeutic use)
- Chronic Disease
- Endopeptidases
(therapeutic use)
- Female
- Follow-Up Studies
- Humans
- Lipase
(therapeutic use)
- Male
- Middle Aged
- Pancreatitis
(drug therapy, psychology)
- Prospective Studies
- Quality of Life
- Steatorrhea
(prevention & control)
- Surveys and Questionnaires
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