An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems.
Abstract |
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Authors | Peggy P Ho, Paulo Fontoura, Pedro J Ruiz, Lawrence Steinman, Hideki Garren |
Journal | Journal of immunology (Baltimore, Md. : 1950)
(J Immunol)
Vol. 171
Issue 9
Pg. 4920-6
(Nov 01 2003)
ISSN: 0022-1767 [Print] United States |
PMID | 14568974
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Adjuvants, Immunologic
- Antigens, CD1
- CD1C protein, human
- Cytokines
- Dinucleoside Phosphates
- Glycoproteins
- GpG-oligonucleotide
- Growth Inhibitors
- Histocompatibility Antigens Class II
- I-kappa B Proteins
- Immunosuppressive Agents
- Myelin Basic Protein
- Myelin Proteolipid Protein
- NF-kappa B
- NFKBIA protein, human
- Nfkbia protein, mouse
- Oligodeoxyribonucleotides
- Peptide Fragments
- myelin basic protein Ac1-11(4Y)
- myelin proteolipid protein (139-151)
- NF-KappaB Inhibitor alpha
- guanylyl-(3'-5')-guanosine
- Serine
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Topics |
- Adjuvants, Immunologic
(administration & dosage, genetics, pharmacology)
- Animals
- Antigen-Presenting Cells
(immunology, metabolism)
- Antigens, CD1
(biosynthesis)
- Autoimmune Diseases
(immunology, pathology)
- Cells, Cultured
- Cytokines
(antagonists & inhibitors, biosynthesis)
- Dinucleoside Phosphates
(administration & dosage, immunology, pharmacology)
- Down-Regulation
(immunology)
- Encephalomyelitis, Autoimmune, Experimental
(immunology, prevention & control)
- Female
- GC Rich Sequence
(genetics, immunology)
- Glycoproteins
(biosynthesis)
- Growth Inhibitors
(pharmacology)
- Histocompatibility Antigens Class II
(biosynthesis)
- I-kappa B Proteins
(antagonists & inhibitors, metabolism)
- Immunity, Innate
(genetics)
- Immunosuppressive Agents
(administration & dosage, pharmacology)
- Lymphocyte Activation
(genetics, immunology)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Myelin Basic Protein
(antagonists & inhibitors, biosynthesis, genetics)
- Myelin Proteolipid Protein
(antagonists & inhibitors, physiology)
- NF-KappaB Inhibitor alpha
- NF-kappa B
(antagonists & inhibitors, metabolism)
- Oligodeoxyribonucleotides
(administration & dosage, immunology, pharmacology)
- Peptide Fragments
(antagonists & inhibitors, biosynthesis, genetics, physiology)
- Phosphorylation
- Serine
(metabolism)
- Spleen
(cytology, immunology)
- Th1 Cells
(immunology, metabolism)
- Th2 Cells
(immunology)
- Up-Regulation
(immunology)
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