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Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung.

AbstractBACKGROUND:
Caveolin-1, as a major component of caveolae, is involved in the regulation of cell cycle by impacting various signaling pathways. Previous studies of caveolin-1 in cancer showed two contrary results. In most in vitro studies, caveolin-1 played a role as a tumor suppressor. On the other hand, the elevated expression of caveolin-1 was often reported to be associated with poor clinical outcome in human studies. These results indicate differential biological functions of caveolin-1 depending on the development and progression stage of cancer in vivo.
METHODS:
To clarify the correlation between the clinicopathologic profiles of pulmonary squamous cell carcinomas and the expression of caveolin-1, 107 cases of formalin-fixed and paraffin-embedded tissues of pulmonary squamous cell carcinomas were immunohistochemically evaluated for the expression of caveolin-1 by the tissue-array method.
RESULTS:
Caveolin-1 was expressed in 34 cases (31.7%) among 107 cases of pulmonary squamous cell carcinoma. The expression of caveolin-1 was statistically correlated with pathologic stage (stage I and II vs. III; P<0.001), pT (T1 and T2 vs. T3 and T4; P=0.001), and pN (N1 vs. N2 and N3; P=0.0143). The patients with caveolin-1 expression in pulmonary squamous cell carcinomas showed a poorer prognosis than those in caveolin-1-negative group (P=0.0345).
CONCLUSION:
The expression of caveolin-1 is significantly correlated with advanced pathologic stage and poor prognosis in pulmonary squamous cell carcinoma. The results of current study suggest that the expression level of caveolin-1 may be a candidate factor for predicting prognosis in patients with pulmonary squamous cell carcinoma.
AuthorsSeong-Ho Yoo, Young Sik Park, Hyeong-Ryul Kim, Sook Whan Sung, Joo Hyun Kim, Young Soo Shim, Soong Deok Lee, Yoon-La Choi, Min-Kyung Kim, Doo Hyun Chung
JournalLung cancer (Amsterdam, Netherlands) (Lung Cancer) Vol. 42 Issue 2 Pg. 195-202 (Nov 2003) ISSN: 0169-5002 [Print] Ireland
PMID14568687 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CAV1 protein, human
  • Caveolin 1
  • Caveolins
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung (pathology)
  • Carcinoma, Squamous Cell (pathology)
  • Caveolin 1
  • Caveolins (biosynthesis)
  • Disease Progression
  • Female
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms (pathology)
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Retrospective Studies
  • Sensitivity and Specificity
  • Survival Analysis

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