Abstract | BACKGROUND:
Caveolin-1, as a major component of caveolae, is involved in the regulation of cell cycle by impacting various signaling pathways. Previous studies of caveolin-1 in cancer showed two contrary results. In most in vitro studies, caveolin-1 played a role as a tumor suppressor. On the other hand, the elevated expression of caveolin-1 was often reported to be associated with poor clinical outcome in human studies. These results indicate differential biological functions of caveolin-1 depending on the development and progression stage of cancer in vivo. METHODS: RESULTS:
Caveolin-1 was expressed in 34 cases (31.7%) among 107 cases of pulmonary squamous cell carcinoma. The expression of caveolin-1 was statistically correlated with pathologic stage (stage I and II vs. III; P<0.001), pT (T1 and T2 vs. T3 and T4; P=0.001), and pN (N1 vs. N2 and N3; P=0.0143). The patients with caveolin-1 expression in pulmonary squamous cell carcinomas showed a poorer prognosis than those in caveolin-1-negative group (P=0.0345). CONCLUSION:
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Authors | Seong-Ho Yoo, Young Sik Park, Hyeong-Ryul Kim, Sook Whan Sung, Joo Hyun Kim, Young Soo Shim, Soong Deok Lee, Yoon-La Choi, Min-Kyung Kim, Doo Hyun Chung |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 42
Issue 2
Pg. 195-202
(Nov 2003)
ISSN: 0169-5002 [Print] Ireland |
PMID | 14568687
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CAV1 protein, human
- Caveolin 1
- Caveolins
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(pathology)
- Carcinoma, Squamous Cell
(pathology)
- Caveolin 1
- Caveolins
(biosynthesis)
- Disease Progression
- Female
- Humans
- Immunohistochemistry
- Lung Neoplasms
(pathology)
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- Retrospective Studies
- Sensitivity and Specificity
- Survival Analysis
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