[Experience with using aclarubicin in the treatment of acute leukemia and blast crisis of chronic myeloid leukemia].

Abstract

The clinical efficacy of aclarubicin, an anthracycline antibiotic, was studied in 48 patients with leukemia. The antibiotic was used in the following combinations with cytarabine: "7 + 7", "5 + 5" and "7 & 3". A complete remission was stated in 14 (42.4 per cent) out of 33 patients with acute nonlymphoid leukemia, 6 (43 per cent) out of the 14 patients having relapses. The combined therapy was effective in 4 out of 5 pre-resistant patients. The "7 + 3" scheme was the most beneficial. The most common adverse reactions were nausea and vomiting.

• Authors: V G Savchenko, V G Isaev, E M Abakumov, N D Khoroshko, A G Turkina, A N Sokolov, M M Viadro, S M Navashin
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 37 Issue 7 Pg. 47-9 (Jul 1992) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Opyt primeneniia aklarubitsina v terapii ostrykh leĭkozov i blastnogo kriza khronicheskogo mieloleĭkoza.
• PMID: 1456812 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Cytarabine
• Aclarubicin

Topics

• Aclarubicin (administration & dosage)
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Blast Crisis (drug therapy)
• Cytarabine (administration & dosage)
• Humans
• Leukemia (drug therapy)
• Leukemia, Monocytic, Acute (drug therapy)
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (drug therapy, pathology)
• Leukemia, Myeloid, Acute (drug therapy)
• Leukemia, Myelomonocytic, Acute (drug therapy)
• Middle Aged
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy)
• Remission Induction