Abstract |
Previous studies suggest that myocardial contrast echocardiography using high mechanical index triggered ultrasound can be associated with increased frequency of the premature ventricular complex ( PVC). However, this association has not been systematically examined. PB127 (Point Biomedical Corp, San Carlos, Calif) is a novel microsphere designed for evaluation of myocardial perfusion with ultrasound. PB127 myocardial contrast echocardiography was performed with triggered harmonic power Doppler in early/mid diastole (mechanical index </= 1.0). A total of 71 patients (cohort A) were studied at rest and another 64 (cohort B, age 62 +/- 12.6 years) were allocated to stress. Continuous electrocardigraphy was recorded. The study evaluated premature ventricular complex frequency at baseline, during, and after infusion of PB127 (dose < 0.175 mg/kg, <60-minute duration). Proportions of triggered and nontriggered intervals associated with premature ventricular complex were determined. PVC frequency did not increase with PB127 infusion in either cohort (P =.572, P =.263). Proportion of triggered intervals after QRS associated with PVC was similar to proportion of untriggered intervals in cohort A (P >.999) and was lower than untriggered intervals (P =.001) in B, suggesting that triggers do not cause PVC. PB127 does not cause increase PVC frequency during or after imaging with triggered ultrasound at mechanical index of 1.
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Authors | Ajit Raisinghani, Kevin S Wei, Linda Crouse, Floredeliza Villanueva, Harvey Feigenbaum, Nelson B Schiller, James Weiss, Tasneem Z Naqvi, Robert Siegel, Mark Monaghan, Jonathan H Goldman, Anthony Demaria, POINT Investigators |
Journal | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
(J Am Soc Echocardiogr)
Vol. 16
Issue 10
Pg. 1037-42
(Oct 2003)
ISSN: 0894-7317 [Print] United States |
PMID | 14566296
(Publication Type: Comparative Study, Evaluation Study, Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Adult
- Aged
- Cohort Studies
- Contrast Media
(adverse effects)
- Coronary Artery Disease
(complications, diagnostic imaging, epidemiology)
- Disease Progression
- Echocardiography
- Electrocardiography, Ambulatory
- Exercise Test
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Myocardial Infarction
(diagnostic imaging, epidemiology, etiology)
- Observer Variation
- Prevalence
- Statistics as Topic
- Ventricular Premature Complexes
(chemically induced, diagnostic imaging, epidemiology)
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