Effect of bupropion SR on specific symptom clusters of depression: analysis of the 31-item Hamilton Rating Scale for depression.

Abstract

Principal component (PC) analysis is a statistical technique that has been used to identify core depression symptoms on the Hamilton Rating Scale for Depression (HAM-D). PC analysis is also a useful method to identify unidimensional scales of the HAM-D that are more sensitive to change following antidepressant treatment. Although there have been previous PC investigations of various versions of the HAM-D, there have been no investigations of the 31-item HAM-D scale or investigations that include subjects administered bupropion SR. We performed a PC analysis on data from 910 outpatients who participated in randomized, double-blind trials evaluating bupropion SR versus placebo for major depression. The goal of our analysis was to 1) identify components (domains) of the 31-item HAM-D and 2) determine patient response to bupropion SR using the domains identified. PC analysis produced a solution comprised of 7 domains of the HAM-D that accounted for approximately 49% of the total variance. Bupropion SR demonstrated a significant reduction (p<.01, least square mean change) in symptoms over placebo on 4 domains (cognitive, retardation, fatigue/interest, and anxiety items).

• Authors: Brenda D Jamerson, K Ranga Rama Krishnan, Jeremy Roberts, Alok Krishen, Jack G Modell
• Journal: Psychopharmacology bulletin (Psychopharmacol Bull) Vol. 37 Issue 2 Pg. 67-78 ( 2003) ISSN: 0048-5764 [Print] United States
• PMID: 14566216 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Antidepressive Agents, Second-Generation
• Delayed-Action Preparations
• Bupropion

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antidepressive Agents, Second-Generation (administration & dosage, therapeutic use)
• Bupropion (administration & dosage, therapeutic use)
• Delayed-Action Preparations
• Depressive Disorder, Major (drug therapy, psychology)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Psychiatric Status Rating Scales