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Rilmenidine produces mydriasis in cats by stimulation of CNS alpha 2-adrenoceptors.

Abstract
1. Experiments were undertaken to determine if the imidazoline/alpha2-adrenoceptor agonist, rilmenidine, would produce mydriasis in cats and, if so, to delineate its site of action and determine if this effect is mediated by imidazoline receptors or alpha2-adrenoceptors. 2. Rilmenidine produced dose-related pupillary dilator responses in pentobarbital anaesthetized cats that were independent of sympathetic innervation to the iris but were dependent upon intact parasympathetic neuronal tone. The ED50 for rilmenidine-induced pupillary dilation was approximately 200 microg kg(-1), i.v., and was sustained for at least 1 h. 3. The highly selective alpha2-adrenoceptor antagonist, RS-79948, administered either before or after rilmenidine, antagonized rilmenidine-induced mydriasis. Neuronally induced reflex inhibition of parasympathetic nerve activity was also inhibited by administration of RS-79948. 4. These results suggest that rilmenidine acts like clonidine to produce pupillary dilation by inhibition of parasympathetic tone to the iris sphincter and that this central nervous system parasympatho-inhibition is mediated by alpha2-adrenoceptors, rather than imidazoline receptors.
AuthorsM C Koss
JournalAutonomic & autacoid pharmacology (Auton Autacoid Pharmacol) Vol. 23 Issue 1 Pg. 51-6 (Feb 2003) ISSN: 1474-8665 [Print] England
PMID14565538 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Adrenergic alpha-2 Receptor Agonists
  • Mydriatics
  • Oxazoles
  • Receptors, Adrenergic, alpha-2
  • Rilmenidine
Topics
  • Adrenergic alpha-2 Receptor Agonists
  • Animals
  • Cats
  • Central Nervous System (drug effects, metabolism)
  • Dose-Response Relationship, Drug
  • Female
  • Male
  • Mydriatics (pharmacology)
  • Oxazoles (pharmacology)
  • Pupil (drug effects, physiology)
  • Receptors, Adrenergic, alpha-2 (metabolism)
  • Rilmenidine

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