Abstract |
The ability of the synthetic retinoid MDI-301, in which the carboxylic acid of 9- cis-retinoic acid (9-cis-RA) is replaced with an ester linkage, to induce epidermal and dermal thickening and skin irritation ( erythema and flaking) in hairless (rhino) mice following its topical application was investigated in comparison with that of 14-all- trans-retinoic acid (14-all-trans-RA) and 9-cis-RA. MDI-301 induced epidermal proliferation leading to a thickened epidermis. Treated animals also demonstrated a prominent band of organized connective tissue immediately below the epidermis. In its ability to induce epidermal thickening, MDI-301 was quantitatively similar to 14-all-trans-RA and 9-cis-RA. However, unlike 14-all-trans-RA and 9-cis-RA, which produced skin irritation associated with a perivascular influx of mononuclear leukocytes into the dermis, there was no evidence of irritation with MDI-301 and little leukocyte infiltration. Intraperitoneal injection of either 14-all-trans-RA or MDI-301 also resulted in epidermal and dermal thickening. Irritation of skin was not observed in these animals but splenomegaly was prominent in animals treated with either agent.
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Authors | James Varani, Helene Fligiel, Jian Zhang, Muhammad Nadeem Aslam, Yi Lu, Lindsay A Dehne, Evan T Keller |
Journal | Archives of dermatological research
(Arch Dermatol Res)
Vol. 295
Issue 6
Pg. 255-62
(Nov 2003)
ISSN: 0340-3696 [Print] Germany |
PMID | 14564458
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- MDI 301
- Retinoids
- Alitretinoin
- Tretinoin
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Topics |
- Alitretinoin
- Animals
- Cells, Cultured
- Dermatitis, Irritant
(pathology)
- Dermis
(pathology)
- Epidermis
(pathology)
- Fibroblasts
(cytology, drug effects)
- Humans
- Keratinocytes
(cytology, drug effects)
- Mice
- Mice, Hairless
- Retinoids
(chemistry, pharmacology)
- Tretinoin
(analogs & derivatives, chemistry, pharmacology)
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