Abstract |
Alendronate (A), a typical aminobisphosphonate ( aminoBP), has a strong bone-resorption-inhibitory activity (BRIA). However, like other aminoBPs it has inflammatory side effects. In contrast, the BRIA of clodronate (C), a non- aminoBP, is much weaker, and in animal experiments it suppresses aminoBP-induced inflammatory reactions. In the present study, we examined the effects of weekly administrations of A (1.6 micro mol/kg) + C (160 micro mol/kg) on the tibias in young mice and compared them to those induced by A or C alone. Radiophotography showed that A increased bone density at a selective site in the tibia. Indeed, one week after the final injection of A (given alone), clear sclerotic lines (tentatively called BP-lines) were visible at sites corresponding to the location of the growth plate at the time of the each injection. C also produced BP-lines, although they were weaker than those produced by A. Combined administration of A and C produced similar BP-lines as seen in mice given A alone. These results together with other physicochemical effects of A on the tibia suggest that (1) each injection of A and C inhibits bone resorption selectively and transiently at the tibial growth plate in young mice, although minor effects on other sites cannot be excluded, and (2) the combination of A and C keeps still a strong BRIA. Our findings may suggest a strategy for the prevention or reduction of some inflammatory side effects of A or other aminoBPs.
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Authors | Y Monma, H Funayama, H Mayanagi, Y Endo |
Journal | Calcified tissue international
(Calcif Tissue Int)
Vol. 74
Issue 1
Pg. 115-21
(Jan 2004)
ISSN: 0171-967X [Print] United States |
PMID | 14564433
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Clodronic Acid
- Calcium
- Alendronate
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Topics |
- Alendronate
(administration & dosage, chemical synthesis, pharmacology)
- Animals
- Anti-Inflammatory Agents
(administration & dosage, chemical synthesis, pharmacology)
- Calcium
(analysis)
- Clodronic Acid
(administration & dosage, chemical synthesis, pharmacology)
- Drug Administration Schedule
- Drug Therapy, Combination
- Growth Plate
(drug effects)
- Male
- Mice
- Mice, Inbred BALB C
- Radiography
- Tibia
(chemistry, diagnostic imaging, drug effects)
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