Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma.

Abstract

AIM:

This study was designed to evaluate the clinical application of serum total sialic acid (TSA) in the diagnosis of cholangiocarcinoma (CCA).

METHODS:

Serum TSA was determined by periodate-resorcinol microassay in 69 patients with CCA, 59 patients with hepatocellular carcinoma (HCC), 37 patients with cirrhosis, 61 patients with chronic hepatitis and 50 healthy blood donors.

RESULTS:

The mean serum TSA concentration in CCA (2.41+/-0.70 mmol/L) was significantly higher than those of HCC, cirrhosis, chronic hepatitis and healthy blood donors (1.41+/-0.37 mmol/L, 1.13+/-0.31 mmol/L, 1.16+/-0.26 mmol/L, and 1.10+/-0.14 mmol/L, respectively; P<0.001). Based on ROC curve analysis, a cut-off point of 1.75 mmol/L discriminated between CCA and HCC with a sensitivity, specificity and accuracy of 82.6 %, 83.1 %, and 82.8 %, respectively.

CONCLUSION:

Based on our results, serum TSA would be a useful marker for the differential diagnosis of CCA from HCC.

• Authors: Prachya Kongtawelert, Pisit Tangkijvanich, Siriwan Ong-Chai, Yong Poovorawan
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 9 Issue 10 Pg. 2178-81 (Oct 2003) ISSN: 1007-9327 [Print] United States
• PMID: 14562373 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• N-Acetylneuraminic Acid

Topics

• Adult
• Aged
• Bile Duct Neoplasms (blood, diagnosis)
• Biomarkers, Tumor (blood)
• Carcinoma, Hepatocellular (blood, diagnosis)
• Cholangiocarcinoma (blood, diagnosis)
• Diagnosis, Differential
• Female
• Hepatitis, Chronic (blood, diagnosis)
• Humans
• Liver Cirrhosis (blood, diagnosis)
• Liver Neoplasms (blood, diagnosis)
• Male
• Middle Aged
• N-Acetylneuraminic Acid (blood)