Treatment of primary mucosal head and neck squamous cell carcinoma using photodynamic therapy: results after 25 treated cases.

Abstract

The use of photodynamic therapy for the treatment of malignant and non-malignant conditions is increasing. This paper demonstrates the efficacy of a second-generation photosensitizer, Foscan, in the primary treatment of a wide range of mucosal head and neck squamous cell carcinomas. Tumours ranged in stage from T(1) to T(3). A complete response to primary treatment was seen in 19/21 patients (90 per cent). In laryngeal cancer recurrent after radical radiotherapy, one out of four patients treated obtained a complete response (25 per cent). Six patients (24 per cent) required surgery after photodynamic therapy, for local recurrence or dysplasia. Mean follow up was for 27.3 months (standard deviation 20.6 months).

• Authors: M G Dilkes, E Benjamin, S Ovaisi, A S Banerjee
• Journal: The Journal of laryngology and otology (J Laryngol Otol) Vol. 117 Issue 9 Pg. 713-7 (Sep 2003) ISSN: 0022-2151 [Print] England
• PMID: 14561360 (Publication Type: Journal Article)

Chemical References

• Mesoporphyrins
• Photosensitizing Agents
• temoporfin

Topics

• Carcinoma, Squamous Cell (drug therapy, radiotherapy, surgery)
• Combined Modality Therapy
• Follow-Up Studies
• Head and Neck Neoplasms (drug therapy, radiotherapy, surgery)
• Humans
• Laryngeal Neoplasms (drug therapy, radiotherapy, surgery)
• Mesoporphyrins (administration & dosage)
• Mouth Neoplasms (drug therapy, radiotherapy, surgery)
• Neoplasm Recurrence, Local (drug therapy, radiotherapy, surgery)
• Oropharyngeal Neoplasms (drug therapy, radiotherapy, surgery)
• Photochemotherapy (methods)
• Photosensitizing Agents (administration & dosage)
• Retrospective Studies
• Treatment Outcome