Functional proteomics of receptor-Ck in the developmental stages of human atherosclerotic arterial wall.

Abstract

BACKGROUND:

The study was undertaken to understand the relationship between the functional proteomics of receptor-Ck and developmental stages of human atherosclerotic aortic wall.

METHODS AND RESULTS:

Gene expression study of 25 aortas was undertaken and the results revealed a gradual increase in receptor-Ck gene expression paralleled by the regulatory response of its effector genes coding for sterol response element-binding protein, p27, cyclin D, interleukin-6 and CD40 from a normal to atherosclerotic arterial wall (viz. fatty streak and fibrofatty/fibrous plaque).

CONCLUSIONS:

Based upon this and our earlier studies, we propose that cholesterol-specific receptor-Ck-dependent gene regulation may be of crucial importance in atherogenesis.

• Authors: D Kaul, R Kaur, I Baba, D Singh
• Journal: Indian heart journal (Indian Heart J) 2003 May-Jun Vol. 55 Issue 3 Pg. 252-5 ISSN: 0019-4832 [Print] India
• PMID: 14560935 (Publication Type: Journal Article)

Chemical References

• CCAAT-Enhancer-Binding Proteins
• Carrier Proteins
• Cyclin D
• Cyclins
• DNA-Binding Proteins
• Interleukin-6
• Microfilament Proteins
• Muscle Proteins
• Receptors, Lipoprotein
• SREBF1 protein, human
• Sterol Regulatory Element Binding Protein 1
• TNF Receptor-Associated Factor 3
• TRAF3 protein, human
• Tagln protein, mouse
• Transcription Factors
• Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
• receptor-Ck

Topics

• Aorta (physiopathology)
• CCAAT-Enhancer-Binding Proteins (genetics)
• Carrier Proteins (genetics)
• Coronary Artery Disease (genetics, physiopathology)
• Cyclin D
• Cyclins (genetics)
• DNA-Binding Proteins (genetics)
• Gene Expression Regulation, Developmental (genetics, physiology)
• Humans
• India
• Interleukin-6 (genetics)
• Microfilament Proteins (genetics)
• Middle Aged
• Muscle Proteins
• Proteomics
• Receptors, Lipoprotein (genetics, physiology)
• Sterol Regulatory Element Binding Protein 1
• TNF Receptor-Associated Factor 3
• Transcription Factors
• Tumor Necrosis Factor Receptor-Associated Peptides and Proteins