[Effect of phensuccinal on lipid metabolism, lipid peroxidation, and antioxidant system activity in rabbits with dithiazone-induced diabetes].

Abstract

A three-month administration of phensuccinal improved glucose homeostasis, decreased the levels of total cholesterol, triglycerides, fatty acids, and low-density lipoproteins in the blood serum, and reduced the lipid peroxidation rate as compared to the untreated diabetic control. In addition, phensuccinal increased the content of the antiatherogenic high-density lipoprotein fraction and the related paraoxonase enzyme activity. The preventive effect of phensuccinal with respect to diabetic dyslipidemia development, together with the antioxidant action, show this compound to be a promising therapeutic means of preventing and/or reducing macrovascular complications in diabetic patients.

• Authors: N I Gorbenko, V V Poltorak, A I Gladkikh, O V Ivanova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2003 Jul-Aug Vol. 66 Issue 4 Pg. 39-42 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vliianie fensuktsinala na lipidnyĭ obmen, perekisnoe okislenie lipidov i aktivnost' antioksidantnoĭ sistemy krolikov s ditiazonovym diabetom.
• PMID: 14558351 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aldehydes
• Antioxidants
• Lipids
• fensuccinal
• Dithizone

Topics

• Aldehydes (pharmacology)
• Animals
• Antioxidants (metabolism, pharmacology)
• Diabetes Mellitus, Experimental (blood, chemically induced, metabolism)
• Dithizone
• Lipid Peroxidation (drug effects)
• Lipids (blood)
• Male
• Rabbits