A randomised comparison of side effects and patient inconvenience of two vaginal progesterone formulations used for luteal support in in vitro fertilisation cycles.

Abstract

OBJECTIVE:

To compare side effects and patient inconvenience of two vaginal progesterone (P) formulations for luteal support in in vitro fertilisation cycles.

STUDY DESIGN:

Sixty infertile patients at risk of developing ovarian hyperstimulation syndrome were randomised to receive either Cyclogest vaginal suppositories 400mg twice daily or Crinone 8% vaginal gel once daily for 14 days as the luteal support. On Day 6 and Day 16 after embryo transfer, they rated side effects and patient inconvenience into four grades: none, mild, moderate and severe by completing a questionnaire.

RESULTS:

Perineal irritation was reported by about 20% of patients in each group. Significantly more patients using Cyclogest suppositories graded inconvenience of administration, leaking out and interference with coitus as moderate or severe.

CONCLUSION:

There was no difference in perineal irritation after Cyclogest suppositories or Crinone 8% gel although significantly more patients found inconvenience of administration, leaking out and interference with coitus after Cyclogest.

• Authors: Ernest H Y Ng, Benyu Miao, Wai Cheung, Pak-Chung Ho
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 111 Issue 1 Pg. 50-4 (Nov 10 2003) ISSN: 0301-2115 [Print] Ireland
• PMID: 14557011 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Crinone
• Irritants
• Progesterone

Topics

• Administration, Intravaginal
• Adult
• Coitus
• Embryo Transfer
• Female
• Fertilization in Vitro (methods)
• Humans
• Irritants (adverse effects)
• Luteal Phase (drug effects)
• Nausea (chemically induced)
• Perineum
• Progesterone (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Time Factors