Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.

Abstract

Cholesterol oxidation products, oxysterols, are thought to play a part in the initiation and development of human atherosclerotic lesions. Excessive body iron has been suggested to promote atherosclerosis and coronary heart disease through its pro-oxidative properties. In the present study, the associations between serum ferritin and plasma oxysterol concentrations were examined in 669 eastern Finnish men. Serum ferritin concentration had statistically significant (p <.05) direct correlations with most of the measured oxysterols. In multivariate adjusted regression models, serum ferritin concentration predicted significantly the levels of 27-hydroxycholesterol (beta = 0.13, p <.001), 7alpha-hydroxycholesterol (beta = 0.11, p =.005), 25-hydroxycholesterol (beta = 0.10, p =.007), 7-ketocholesterol (beta = 0.10, p =.009), and 7beta-hydroxycholesterol (beta = 0.10, p =.02). In conclusion, excess body iron, as assessed by serum ferritin, is associated with increased levels of circulating oxysterols, both of enzymatic and nonenzymatic origin, in man.

• Authors: Tomi-Pekka Tuomainen, Ulf Diczfalusy, Jari Kaikkonen, Kristiina Nyyssönen, Jukka T Salonen
• Journal: Free radical biology & medicine (Free Radic Biol Med) Vol. 35 Issue 8 Pg. 922-8 (Oct 15 2003) ISSN: 0891-5849 [Print] United States
• PMID: 14556856 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Fatty Acids
• Hydroxycholesterols
• 27-hydroxycholesterol
• 25-hydroxycholesterol
• Ferritins
• Cholesterol

Topics

• Adult
• Cholesterol (blood)
• Fatty Acids (blood)
• Ferritins (blood)
• Humans
• Hydroxycholesterols (blood)
• Male
• Middle Aged
• Oxidation-Reduction