No evidence for association between the polymorphism in the 3' untranslated region of interleukin-12B and human susceptibility to tuberculosis.

Abstract

Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3' untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3' UTR has no effect or has a negligible effect on human susceptibility to TB.

• Authors: Xin Ma, Robert A Reich, Omar Gonzalez, Xi Pan, Amanda K Fothergill, Jeffery R Starke, Larry D Teeter, James M Musser, Edward A Graviss
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 188 Issue 8 Pg. 1116-8 (Oct 15 2003) ISSN: 0022-1899 [Print] United States
• PMID: 14551880 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 3' Untranslated Regions
• IL12B protein, human
• Interleukin-12 Subunit p40
• Interleukin-12

Topics

• 3' Untranslated Regions (genetics)
• Adult
• Black People
• Case-Control Studies
• Child
• Female
• Genetic Predisposition to Disease
• Humans
• Interleukin-12 (genetics)
• Interleukin-12 Subunit p40
• Linkage Disequilibrium
• Male
• Mycobacterium tuberculosis
• Polymorphism, Genetic
• Polymorphism, Single Nucleotide
• Tuberculosis, Pulmonary (ethnology, genetics)
• White People