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Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in nonsteroidal anti-inflammatory drug users--a randomized trial.

AbstractAIM:
To study whether prophylaxis with lansoprazole could prevent relapse of ulcers after eradication of Helicobacter pylori in patients with NSAID-related peptic ulcers.
METHODS:
Patients who presented with peptic ulcers and were found to be infected with H. pylori while receiving NSAIDs were recruited into the study. They received, twice daily, lansoprazole 30 mg, amoxicillin 1 g and clarithromycin 500 mg for 1 week, followed by lansoprazole 30 mg daily for 4 weeks. Patients with healed ulcers and H. pylori eradicated were given naproxen 750 mg daily, and randomly assigned to receive lansoprazole 30 mg daily or no treatment for 8 weeks. The primary endpoint was the cumulative recurrence of symptomatic and complicated ulcers.
RESULTS:
At the end of the 8-week treatment period, significantly fewer patients (1/22, 4.5%, 95% confidence interval [CI] 0-23) in the lansoprazole group compared with the group that received H. pylori eradication alone (9/21, 42.9%, 95% CI 22-66) developed recurrence of symptomatic and complicated ulcers (log rank test P=0.0025).
CONCLUSIONS:
Lansoprazole significantly reduced the cumulative relapse of symptomatic and complicated ulcers in patients requiring NSAIDs after eradication of H. pylori.
AuthorsK C Lai, S K Lam, K M Chu, W M Hui, K F Kwok, B C Y Wong, H C Hu, W M Wong, O O Chan, C K Chan
JournalAlimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 18 Issue 8 Pg. 829-36 (Oct 15 2003) ISSN: 0269-2813 [Print] England
PMID14535877 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Ulcer Agents
  • Lansoprazole
  • Amoxicillin
  • Clarithromycin
  • Omeprazole
Topics
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amoxicillin (therapeutic use)
  • Anti-Bacterial Agents (therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
  • Anti-Ulcer Agents (therapeutic use)
  • Clarithromycin (therapeutic use)
  • Dyspepsia (etiology)
  • Endoscopy, Gastrointestinal
  • Female
  • Follow-Up Studies
  • Helicobacter Infections (drug therapy)
  • Helicobacter pylori
  • Humans
  • Lansoprazole
  • Male
  • Middle Aged
  • Omeprazole (analogs & derivatives, therapeutic use)
  • Patient Compliance
  • Peptic Ulcer (chemically induced, drug therapy)
  • Secondary Prevention
  • Treatment Outcome

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