In order to explore the effect of
sodium iron ethylenediaminetetraacetate (
NaFeEDTA) on preventing rats from
lead poisoning and reducing the lead toxicity, and at the same time to explore its impact on
zinc and
copper, sixty Wistar rats were randomly divided into six groups including blank control group, model control group, positive control group and three different level
NaFeEDTA (high, middle and low) groups. With the exception of the blank control group, which only received double distilled water treatment throughout the experiment, all the other rats were continuously treated with lead
solution. At the same time, with the exception of the blank and model control groups, the other four groups were treated with acidi dimercaptosuccinici (
DMSA), high, middle and low level
NaFeEDTA solutions respectively. At the end of the study, several indicators were determined. The results showed that the
hemoglobin levels in the three different level
NaFeEDTA groups were significantly higher than those of the other four groups and at the same time the lead levels in blood and organs were lower than those of model group significantly. There were significant reverse correlations between
iron supplement and the lead levels in liver, kidney and tibia among the three different level
NaFeEDTA groups, and the correlation coefficients were -0.4432, -0.6134 and -0.3878 respectively. There were no significant differences in
zinc levels and
copper levels between the three level
NaFeEDTA groups and the negative control group except the brain
zinc levels in the middle and high level
NaFeEDTA groups were lower and the kidney
copper level in the low level
NaFeEDTA group was higher than those of the model control group. It is concluded that the
NaFeEDTA can effectively improve
hemoglobin level, prevent rats from
lead poisoning and reduce the lead toxicity. At the same time,
NaFeEDTA does not have significant influence on
zinc and
copper levels in rats.