Abstract |
The effects of nine potential cancer chemopreventive agents on cell growth or clonogenic survival were evaluated in normal human prostate epithelial cells, an immortalized but non-tumorigenic human prostate epithelial cell line (267B1), a human benign prostatic hyperplasia (BPH) cell line (BRF-55T), and a human prostate cancer cell line (267B1/Ki-ras). Of the nine agents tested, 9-cis retinoic acid, liarozole fumarate, phenylenebis(methylene)- selenocyanate (p-XSC), and L- selenomethionine demonstrated much stronger growth inhibitory effects on prostate cancer cells than on the normal prostate epithelial cells, suggesting that these agents may be useful as prostate cancer chemopreventive agents. 9-cis retinoic acid, genistein, liarozole fumarate, p-XSC, L- selenomethionine and vitamin E also showed much stronger growth inhibitory effects on BRF-55T cells than on the normal prostate epithelial cells, indicating that these agents may also be useful for the prevention and treatment of BPH. Difluoromethylornithine (DFMO), DHEA analogue 8354 ( fluasterone), and oltipraz did not show strong inhibitory effects on the growth or survival of normal prostate epithelial cells, 267B1 or 267B1/Ki-ras cells, suggesting that these agents may not be effective as prostate cancer preventive or therapeutic agents.
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Authors | X Steven Wan, Zhoazong Zhou, Ann R Kennedy, Levy Kopelovich |
Journal | Oncology reports
(Oncol Rep)
2003 Nov-Dec
Vol. 10
Issue 6
Pg. 2009-14
ISSN: 1021-335X [Print] Greece |
PMID | 14534735
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Epithelial Cells
(drug effects)
- Humans
- In Vitro Techniques
- Male
- Prostate
(drug effects, pathology)
- Prostatic Neoplasms
(drug therapy, prevention & control)
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