Abstract | PURPOSE: MATERIALS AND METHODS: A total of 20 New Zealand male rabbits were used in the first phase of the experiment. Bulbar urethral stricture was induced by electrocoagulation. The animals were then randomly assigned to 2 groups of 10 each, which received a diet containing halofuginone or a normal diet. In the second phase electrocoagulation induced stricture was treated with visual internal urethrotomy in 45 rabbits. These rabbits were randomly assigned to 2 groups, namely a halofuginone and a control group. RESULTS: In the first phase stricture developed in 2 study rabbits (20%) vs 10 controls (100%). In the second phase 37 rabbits were evaluable (8 died). Recurrent stricture was observed in 5 of the 18 study rabbits (27%) vs 14 of the 19 controls (73%). CONCLUSIONS:
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Authors | Mehdi Jaidane, Bedeir Ali-El-Dein, Abdelahad Ounaies, Ashraf T Hafez, Tarek Mohsen, Mahmoud Bazeed |
Journal | The Journal of urology
(J Urol)
Vol. 170
Issue 5
Pg. 2049-52
(Nov 2003)
ISSN: 0022-5347 [Print] United States |
PMID | 14532851
(Publication Type: Journal Article)
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Chemical References |
- Piperidines
- Protein Synthesis Inhibitors
- Quinazolines
- Quinazolinones
- halofuginone
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Topics |
- Administration, Oral
- Animals
- Electrocoagulation
- Fibrosis
(pathology)
- Male
- Piperidines
- Protein Synthesis Inhibitors
(pharmacology)
- Quinazolines
(pharmacology)
- Quinazolinones
- Rabbits
- Secondary Prevention
- Urethra
(drug effects, pathology, surgery)
- Urethral Stricture
(pathology)
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