Abstract | BACKGROUND: METHODS: Twelve pigs (weight, 35 to 55 kg) were divided into two groups of six. Baseline ventricular function studies were based on echocardiography, conductance, aortic flow, and LV pressure. Animals were given vehicle (control) or cariporide (3 mg/kg intravenously). Ten minutes later, hearts underwent 80 seconds of VF. After reperfusion for 40 minutes, function studies were repeated. RESULTS: Postmortem examination included measuring passive pressure-volume curves and myocardial water content. Systolic indices, including preload recruitable stroke work and ejection fraction, were significantly depressed from baseline after VF and reperfusion for control animals (preload recruitable stroke work, 30.13 +/- 0.59 [standard error of the mean] versus 43.85 +/- 2.60 mm Hg; ejection fraction, 25.7% +/- 2.4% versus 33.5% +/- 3.0%) but not for those in the cariporide group (preload recruitable stroke work, 38.36 +/- 1.87 versus 40.86 +/- 1.45 mm Hg; ejection fraction, 33.9% +/- 3.5% versus 32.8% +/- 3.9%). In vivo diastolic indices demonstrated trends toward diminished ventricular compliance in control animals but not in the cariporide group after VF and reperfusion. Control animals had significantly increased postmortem LV stiffness, myocardial water content, and normalized LV mass. CONCLUSIONS:
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Authors | David G Rabkin, Santos E Cabreriza, Faisal H Cheema, Adam A Hill, Lauren J Curtis, Robert R Sciacca, Ralph S Mosca, Henry M Spotnitz |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 76
Issue 4
Pg. 1264-9; discussion 1269
(Oct 2003)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 14530023
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Arrhythmia Agents
- Guanidines
- Sulfones
- cariporide
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Topics |
- Animals
- Anti-Arrhythmia Agents
(pharmacology, therapeutic use)
- Defibrillators, Implantable
(adverse effects)
- Guanidines
(pharmacology, therapeutic use)
- Iatrogenic Disease
(prevention & control)
- Male
- Sulfones
(pharmacology, therapeutic use)
- Swine
- Ventricular Fibrillation
(etiology, prevention & control)
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