Abstract |
The clinical and bacteriological activity of fosfomycin trometamol (FT) has been compared with several other antibiotics in the treatment of uncomplicated urinary tract infections. A single dose of FT had activity comparable with a 5-day course of trimethoprim in a trial where the causative organism and its sensitivity were unknown. In another trial FT showed better long term eradication compared with a 5-day course of cephalexin and other studies suggested a single dose of FT was comparable with a 7-day course of nitrofurantoin or norfloxacin. There were few important side effects with fosfomycin therapy and it was considered a safe and effective first line treatment in uncomplicated urinary tract infection.
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Authors | B Lobel |
Journal | International journal of antimicrobial agents
(Int J Antimicrob Agents)
Vol. 22 Suppl 2
Pg. 85-7
(Oct 2003)
ISSN: 0924-8579 [Print] Netherlands |
PMID | 14527777
(Publication Type: Comparative Study, Journal Article, Review)
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Chemical References |
- Anti-Bacterial Agents
- Fosfomycin
- Nitrofurantoin
- Trimethoprim
- Norfloxacin
- Cephalexin
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Topics |
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Bacterial Infections
(drug therapy)
- Cephalexin
(therapeutic use)
- Clinical Trials as Topic
- Dose-Response Relationship, Drug
- Female
- Fosfomycin
(administration & dosage, therapeutic use)
- Humans
- Longitudinal Studies
- Meta-Analysis as Topic
- Nitrofurantoin
(administration & dosage, therapeutic use)
- Norfloxacin
(therapeutic use)
- Treatment Outcome
- Trimethoprim
(therapeutic use)
- Urinary Tract Infections
(drug therapy)
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