Association of HLA class I alleles with psoriasis vulgaris in southeastern Chinese Hans.

Abstract

BACKGROUND:

Predisposing genetic factors in psoriasis include associations with human leukocyte antigen (HLA). Accumulative evidence has shown that certain HLA at class I locus, especially HLA-Cw6, are associated closely with psoriasis.

OBJECTIVE:

To evaluate the association of HLA class I alleles with susceptibility to psoriasis in the southeastern Chinese Han population.

METHODS:

We performed genotype for HLA-A, -B and -C loci in 166 patients with psoriasis vulgaris by means of polymerase chain reaction with sequence-specific primers technique. The distribution of HLA allelic frequencies was further analyzed according to age of onset, i.e. under 35-y and beyond 35-y groups. These data were compared with the healthy controls of 204 unrelated Hans.

RESULTS:

The frequencies of HLA-A*26 (24.7% vs. 13.1%, OR=2.36, Pc<0.01), -B*13 (27.2% vs. 14.8%, OR=2.34, Pc<0.01), -B*27 (12.2% vs. 4.0%, OR=3.49, Pc<0.01) and -Cw*0602 (17.9% vs. 5.3%, OR=4.20, Pc<0.001) were significantly increased in psoriasis patients, whereas HLA-Cw*0304 frequency (4.9% vs. 13.4%, OR=0.32, Pc<0.01) was highly decreased, when compared to the controls. HLA-A*26-B*27-Cw*0602 was identified as a high-risk haplotype of HLA class I in developing psoriasis in the test. HLA-Cw*0602 was found to be strongly associated with the early-onset psoriasis (age of onset <35 y).

CONCLUSION:

This study demonstrated the positive associations of HLA class I markers with psoriasis vulgaris, of which HLA-Cw*0602 was the strongest susceptibility determinant for development of early-onset psoriasis, in the southeastern Chinese Han population.

• Authors: Xue-Jun Zhang, An-Ping Zhang, Sen Yang, Min Gao, Sheng-Cai Wei, Ping-Ping He, Hong-Yan Wang, Ying-Xue Song, Yong Cui, Jian-Jun Chen
• Journal: Journal of dermatological science (J Dermatol Sci) Vol. 33 Issue 1 Pg. 1-6 (Oct 2003) ISSN: 0923-1811 [Print] Netherlands
• PMID: 14527733 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-A Antigens
• HLA-B Antigens
• HLA-C Antigens
• Histocompatibility Antigens Class I

Topics

• Adult
• Age of Onset
• Alleles
• Asian People (genetics)
• Chromosome Mapping
• Female
• Gene Frequency
• HLA-A Antigens (genetics)
• HLA-B Antigens (genetics)
• HLA-C Antigens (genetics)
• Haplotypes
• Histocompatibility Antigens Class I (genetics)
• Humans
• Male
• Psoriasis (epidemiology, genetics, immunology)