Abstract |
During recent years, a resurgence of interest in the macrolides had led to the discovery of new derivatives of erythromycin with improved antibacterial activity and pharmacokinetic properties. In this study the in-vitro and in-vivo antistaphylococcal activity of S-5556, a 16-membered macrolide, was evaluated. In vitro, S-5556 was slightly less active than erythromycin against methicillin-susceptible Staphylococcus aureus. In contrast, it had superior activity for methicillin-resistant S. aureus (MRSA); several of these strains with inducible resistance to the macrolides- lincosamides- streptogramins group were susceptible to S-5556 whereas erythromycin was inactive. The combination of S-5556 with oxacillin was synergic for most MRSA strains tested. In vivo, a single prophylactic dose of S-5556 prevented 75%-100% of the cases of acute staphylococcal subcutaneous foreign body infection in a guinea pig-model. In a rat-model of chronic implant infection due to a methicillin- and erythromycin-resistant S. aureus strain, S-5556 significantly decreased the bacterial concentration around the foreign material, however resistant mutants emerged.
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Authors | C Chuard, P Rohner, V Dunand, R Auckenthaler, D P Lew |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 30
Issue 3
Pg. 327-37
(Sep 1992)
ISSN: 0305-7453 [Print] England |
PMID | 1452498
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Coagulase
- para-nitrobenzyl-oxime-tylosine
- Tylosin
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Topics |
- Animals
- Anti-Bacterial Agents
(pharmacology)
- Coagulase
(analysis)
- Disease Models, Animal
- Drug Synergism
- Foreign Bodies
(complications)
- Guinea Pigs
- Methicillin Resistance
- Microbial Sensitivity Tests
- Rats
- Skin
- Species Specificity
- Staphylococcal Skin Infections
(prevention & control)
- Staphylococcus aureus
(drug effects, enzymology)
- Tylosin
(analogs & derivatives, pharmacology)
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