Selectin and selectin ligand binding: a bittersweet attraction.

Abstract

Inhibition of leukocyte migration into target organs has long been an attractive, though challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of leukocyte rolling along blood vessels has not yielded successful new therapies. An important study may now open new avenues in this exciting field of anti-inflammatory therapies by introducing a putative inhibitor of poly-N-acetyllactosamine biosynthesis that affects selectin ligand activity and shows efficacy in a rodent skin inflammation model.

• Authors: Thomas M Zollner, Khusru Asadullah
• Journal: The Journal of clinical investigation (J Clin Invest) Vol. 112 Issue 7 Pg. 980-3 (Oct 2003) ISSN: 0021-9738 [Print] United States
• PMID: 14523033 (Publication Type: Journal Article, Comment)

Chemical References

• Antigens, Differentiation, T-Lymphocyte
• Antigens, Neoplasm
• CTAGE1 protein, human
• E-Selectin
• Membrane Glycoproteins
• Oligosaccharides
• P-selectin ligand protein
• Sialyl Lewis X Antigen
• 2-acetamido-1,3,6-tri-O-acetyl-4-deoxy-4-fluoroglucopyranose
• Acetylglucosamine

Topics

• Acetylglucosamine (analogs & derivatives, pharmacology)
• Animals
• Antigens, Differentiation, T-Lymphocyte
• Antigens, Neoplasm
• Cell Movement
• Dermatitis, Contact (immunology, prevention & control)
• E-Selectin (metabolism)
• Endothelium, Vascular (cytology)
• Membrane Glycoproteins (metabolism)
• Mice
• Oligosaccharides (biosynthesis)
• Sialyl Lewis X Antigen
• Skin (immunology)
• T-Lymphocytes (physiology)