Action of prostanoids on the emetic reflex of Suncus murinus (the house musk shrew).

Several prostanoids were investigated for a potential to induce emesis in Suncus murinus. The TP receptor agonist 11alpha,9alpha-epoxymethano-15S-hydroxyprosta-5Z,13E-dienoic acid (U46619) induced emesis at doses as low as 3 microg/kg, i.p. but the DP receptor agonist 5-(6-Carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin (BW245C) was approximately 1000 times less potent. The emetic action of U46619 (300 microg/kg, i.p.) was antagonized significantly by the TP receptor antagonist, vapiprost (P<0.05). EP (prostaglandin E(2), 17-phenyl-omega-trinor prostaglandin E(2), misoprostol and sulprostone), FP (prostaglandin F(2alpha) and fluprostenol) and IP (iloprost and cicaprost) receptor agonists failed to induce consistent emesis at doses up to 300-1000 microg/kg, i.p. Fluprostenol reduced nicotine (5 mg/kg, s.c.)-but not copper sulphate (120 mg/kg, intragastric)-induced emesis; the other inconsistently emetic prostanoids were inactive to modify drug-induced emesis. The results indicate an involvement of TP and possibly DP and FP receptors in the emetic reflex of S. murinus.
AuthorsKelvin K W Kan, Robert L Jones, Man P Ngan, John A Rudd
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 477 Issue 3 Pg. 247-51 (Sep 23 2003) ISSN: 0014-2999 [Print] Netherlands
PMID14522363 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biphenyl Compounds
  • Heptanoic Acids
  • Hydantoins
  • Prostaglandins
  • Prostaglandins F, Synthetic
  • Receptors, Thromboxane
  • fluprostenol
  • Nicotine
  • BW 245C
  • 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
  • vapiprost
  • Copper Sulfate
  • 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid (administration & dosage, adverse effects, antagonists & inhibitors)
  • Animals
  • Biphenyl Compounds (administration & dosage, pharmacokinetics, therapeutic use)
  • Copper Sulfate (administration & dosage, adverse effects)
  • Dose-Response Relationship, Drug
  • Female
  • Heptanoic Acids (administration & dosage, pharmacokinetics, therapeutic use)
  • Hydantoins (administration & dosage)
  • Injections, Intraperitoneal
  • Injections, Subcutaneous
  • Intubation, Gastrointestinal
  • Male
  • Nausea (physiopathology)
  • Nicotine (administration & dosage, adverse effects, antagonists & inhibitors)
  • Prostaglandins (administration & dosage, adverse effects)
  • Prostaglandins F, Synthetic (administration & dosage, pharmacokinetics, therapeutic use)
  • Reaction Time
  • Receptors, Thromboxane (drug effects, physiology)
  • Shrews (physiology)
  • Time Factors
  • Vomiting (chemically induced, physiopathology, prevention & control)

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