Effect of a fixed dorzolamide-timolol combination on intraocular pressure after small-incision cataract surgery with Viscoat.

Abstract

PURPOSE:

To evaluate the effect of a fixed dorzolamide-timolol combination (Cosopt) on intraocular pressure (IOP) after small-incision cataract surgery with sodium chondroitin sulfate 4%-sodium hyaluronate 3% (Viscoat).

SETTING:

Department of Ophthalmology, University of Vienna, Vienna, Austria.

METHODS:

This prospective randomized study comprised 76 eyes of 38 patients scheduled for small-incision cataract surgery in both eyes. Patients were randomized to receive 1 drop of the fixed dorzolamide-timolol combination in 1 eye or no treatment (control) immediately after cataract surgery. The fellow eye received the other assigned treatment. Cataract surgery was performed with Viscoat in an identical fashion in both eyes. The IOP was measured preoperatively and 6 hours, 20 to 24 hours, and 1 week postoperatively.

RESULTS:

Six hours after surgery, the mean increase in IOP was significantly lower in the dorzolamide-timolol group than in the control group (4.3 mm Hg +/- 5.6 [SD] versus 8.4 +/- 6.1 mm Hg; P =.003). Two eyes in the dorzolamide-timolol group and 9 in the control group had IOP spikes of 30 mm Hg or higher (P =.022). Twenty to 24 hours after surgery, the mean IOP change was -2.6 +/- 3.3 mm Hg in the dorzolamide-timolol group and 1.5 +/- 3.2 mm Hg in the control group (P<.001).

CONCLUSIONS:

The fixed dorzolamide-timolol combination was effective in reducing IOP 6 hours and 20 to 24 hours after cataract surgery. However, it did not prevent Viscoat-induced IOP spikes of 30 mm Hg or higher.

• Authors: Georg Rainer, Rupert Menapace, Oliver Findl, Stefan Sacu, Katja Schmid, Vanessa Petternel, Barbara Kiss, Michael Georgopoulos
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 29 Issue 9 Pg. 1748-52 (Sep 2003) ISSN: 0886-3350 [Print] United States
• PMID: 14522295 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Sulfonamides
• Thiophenes
• chondroitin sulfate, sodium hyaluronate drug combination
• Timolol
• Hyaluronic Acid
• Chondroitin
• Chondroitin Sulfates
• dorzolamide

Topics

• Aged
• Aged, 80 and over
• Cataract Extraction (methods)
• Chondroitin (adverse effects, therapeutic use)
• Chondroitin Sulfates
• Double-Blind Method
• Drug Combinations
• Female
• Humans
• Hyaluronic Acid (adverse effects, therapeutic use)
• Intraocular Pressure (drug effects)
• Male
• Sulfonamides (therapeutic use)
• Thiophenes (therapeutic use)
• Time Factors
• Timolol (therapeutic use)