Antiviral activity of 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one on poliovirus.

Abstract

2-Amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 microg/ml and 2 microg/ml with maximal antiviral acitivity at 1 microg/ml. These results suggest that Phx may be useful to prevent the proliferation of poliovirus infection.

• Authors: Akiko Iwata, Teruhide Yamaguchi, Kouei Sato, Ryutaro Izumi, Akio Tomoda
• Journal: The Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 200 Issue 3 Pg. 161-5 (Jul 2003) ISSN: 0040-8727 [Print] Japan
• PMID: 14521260 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one
• Antiviral Agents
• Oxazines

Topics

• Animals
• Antiviral Agents (pharmacology, toxicity)
• Cell Survival (drug effects)
• Chlorocebus aethiops
• Cytopathogenic Effect, Viral (drug effects)
• Dose-Response Relationship, Drug
• Oxazines (pharmacology, toxicity)
• Poliovirus (drug effects, growth & development)
• Vero Cells