[Tilidine/naloxon retard in long-term administration in chronic pain and multimorbidity. Multicenter study of long-term tolerance and effectiveness in 2 years observation].

Abstract

BACKGROUND AND METHOD:

335 patients (51% female, 49% male, mean age 56 years) with chronic pain and multimorbidity have been included in a multi-center 2-years' study with slow release Tilidine/Naloxone for efficacy and safety which included detailed laboratory examinations. 316 patients had already been treated with analgesics. 159 patients (47.5%) finished the study as planned, 176 patients finished the study earlier.

RESULTS:

Parameters of quality of life such as persistent pain, sleep, mood and activity have improved. Tolerance has not been observed. In 85 patients (25%) adverse events had occurred (nausea, vomiting, dizziness) which are related to the study-medication. Constipation was documented in only 4 patients. After 2 years of therapy with Tilidine/Naloxone there has been no relevant changes in laboratory findings. There has been no sign of organ damage or interactions with concomitant medication.

CONCLUSION:

Tilidine/Naloxone is an effective and safe analgesic (WHO II) suitable for the longterm treatment of patients with chronic pain.

• Authors: Th Flöter, U Brunnmüller
• Journal: Fortschritte der Medizin. Originalien (Fortschr Med Orig) Vol. 120 Issue 1 Pg. 29-35 ( 2002) Germany
• Vernacular Title: Tilidin/Naloxon retard zur Langzeitanwendung bei chronischen Schmerzen und Multimorbidität. Multizenterstudie zur Langzeitverträglichkeit und Wirksamkeit bei zweijähriger Beobachtung.
• PMID: 14518355 (Publication Type: Clinical Trial, Clinical Trial, Phase IV, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Analgesics, Opioid
• Delayed-Action Preparations
• Drug Combinations
• Valoron N
• Naloxone
• Tilidine

Topics

• Adult
• Aged
• Aged, 80 and over
• Analgesics, Opioid (administration & dosage, adverse effects)
• Chronic Disease
• Comorbidity
• Delayed-Action Preparations
• Dose-Response Relationship, Drug
• Drug Combinations
• Drug Therapy, Combination
• Female
• Humans
• Long-Term Care
• Male
• Middle Aged
• Naloxone (administration & dosage, adverse effects)
• Pain (classification, drug therapy)
• Pain Measurement
• Quality of Life
• Tilidine (administration & dosage, adverse effects)
• Treatment Outcome