Involvement of haloperidol-sensitive sigma-sites in antitussive effects.

Abstract

The effects of selective sigma-ligands on the capsaicin-induced cough reflex in rats were studied. Intraperitoneal injection of (+)-N-allylnormetazocine ((+)-SKF-10,047) and N,N'-di(ortho-tolyl)guanidine (DTG) in doses that ranged from 0.3 to 3.0 mg/kg decreased the number of coughs dose dependently. The antitussive effects of these sigma-ligands were significantly attenuated by pretreatment with haloperidol. Pretreatment with haloperidol also markedly reduced the antitussive effects of (+/-)-pentazocine and dextromethorphan. These results suggest that haloperidol-sensitive sigma-sites may be involved in the regulation of coughs.

• Authors: J Kamei, Y Iwamoto, N Kawashima, H Hitosugi, M Misawa, Y Kasuya
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 224 Issue 1 Pg. 39-43 (Nov 24 1992) ISSN: 0014-2999 [Print] Netherlands
• PMID: 1451741 (Publication Type: Journal Article)

Chemical References

• Antitussive Agents
• Guanidines
• Receptors, sigma
• SK&F 10047
• Phenazocine
• Haloperidol
• 1,3-ditolylguanidine
• Capsaicin

Topics

• Animals
• Antitussive Agents (pharmacology)
• Capsaicin
• Cough (chemically induced, drug therapy)
• Dose-Response Relationship, Drug
• Drug Interactions
• Guanidines (pharmacology)
• Haloperidol (pharmacology)
• Injections, Intraperitoneal
• Male
• Phenazocine (administration & dosage, analogs & derivatives, pharmacology)
• Rats
• Rats, Sprague-Dawley
• Receptors, sigma (drug effects)
• Stereoisomerism