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Nuclear proteins of hamster hepatoma after administration of antitumour agents.

Abstract
One- and two-dimensional gel electrophoretic analysis of nuclear proteins of Kirkman-Robbins hepatoma was used to study the effects of the tumour growth inhibitors methotrexate (MTX) and acyclonucleoside (DHPQtB) on protein composition. MTX and DHPQtB inhibited Kirkman-Robbins hepatoma growth by 89.2 +/- 3.5% and 16.3 +/- 6.1% respectively. The biosynthesis and/or metabolism of some polypeptide spots was affected by these antitumour agents, especially among components with molecular wt/isoelectric points of 52,000-64,000/4.9-5.5, 69,000-78,000/5.0-5.9 and 88,000-100,000/5.1-5.9.
AuthorsZ Kiliańska, A Lipińska, W M Krajewska, M Gaczyński, J Bartkowiak, L Kłyszejko-Stefanowicz
JournalCytobios (Cytobios) Vol. 70 Issue 281 Pg. 91-100 ( 1992) ISSN: 0011-4529 [Print] England
PMID1451536 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antimetabolites, Antineoplastic
  • Neoplasm Proteins
  • Nuclear Proteins
  • Quinazolines
  • 1-N-(1,3-dihydroxy-2-propoxymethyl)-6-(tert-butyl)-5,6,7,8-tetrahydro-2,4-quinazolinedione
  • Testosterone
  • Methotrexate
Topics
  • Animals
  • Antimetabolites, Antineoplastic (pharmacology, therapeutic use)
  • Cricetinae
  • Depression, Chemical
  • Electrophoresis, Gel, Two-Dimensional
  • Electrophoresis, Polyacrylamide Gel
  • Gene Expression Regulation, Neoplastic (drug effects)
  • Liver Neoplasms, Experimental (chemistry, drug therapy)
  • Male
  • Mesocricetus
  • Methotrexate (pharmacology, therapeutic use)
  • Molecular Weight
  • Neoplasm Proteins (isolation & purification, metabolism)
  • Neoplasms, Hormone-Dependent (chemistry, drug therapy)
  • Nuclear Proteins (isolation & purification, metabolism)
  • Quinazolines (pharmacology, therapeutic use)
  • Testosterone

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