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Calciphylaxis in chronic, non-dialysis-dependent renal disease.

AbstractBACKGROUND:
Calciphylaxis cutis is characterized by media calcification of arteries and, most prominently, of cutaneous and subcutaneous arterioles occurring in renal insufficiency patients.
CASE REPORT:
A 53-year-old woman with chronic cardiac and renal failure complained of painful crural, non-varicosis ulcers. She was hospitalized in an immobilized condition due to both the crural ulcerations and the existing heart-failure state (NYHA III-IV) having pleural and pericardial effusions, atrial fibrillation and weight loss of 30 kg over the past year. Despite normalization of calcium-phosphorus balance and improvement of renal function, the clinical course of crural ulcerations deteriorated during the following 3 months. After failure of surgical debridements, multiple courses of sterile-maggot therapy were introduced at a late stage to stabilize the wounds. The patient died of recurrent wound infections and sepsis paralleled by exacerbations of renal malfunction.
CONCLUSIONS:
The role of renal disease in vascular complications is discussed. Sterile-maggot debridement may constitute a therapy for the ulcerated calciphylaxis at an earlier stage, i.e. when first ulcerations appear.
AuthorsRainer U Pliquett, Jörg Schwock, Ralf Paschke, Harald Achenbach
JournalBMC nephrology (BMC Nephrol) Vol. 4 Pg. 8 (Sep 29 2003) ISSN: 1471-2369 [Electronic] England
PMID14514359 (Publication Type: Case Reports, Journal Article)
Topics
  • Anemia (blood, etiology)
  • Calciphylaxis (blood, complications, pathology)
  • Fatal Outcome
  • Female
  • Heart Failure (blood, complications)
  • Humans
  • Kidney Failure, Chronic (blood, complications)
  • Leg Ulcer (complications, pathology)
  • Middle Aged

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